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Article

Role of replication protein A in double holliday junction dissolution mediated by the BLM-Topo IIIα-RMI1-RMI2 protein complex.

The Journal of biological chemistry - 17 May 2013

Xue Xiaoyu, Raynard Steven, Busygina Valeria, Singh Akhilesh K, Sung Patrick

Abstract excerpt

The conserved BTR complex, composed of the Bloom's syndrome helicase (BLM), topoisomerase IIIα, RMI1, and RMI2, regulates homologous recombination in favor of non-crossover formation via the dissolution of the double Holliday Junction (dHJ). Here we show enhancement of the BTR-mediated dHJ dissol...

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Source

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Identifiers

PMID: 23543748
DOI: 10.1074/jbc.M113.465609
PMCID: PMC3656278

Genes

RMI1
BLM
RMI2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23543748-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Role of replication protein A in double holliday junction dissolution mediated by the BLM-Topo IIIα-RMI1-RMI2 protein complex.PMID 23543748Read ↗

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BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates.Semantic proximity Read ↗

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Human topoisomerase IIIalpha is a single-stranded DNA decatenase that is stimulated by BLM and RMI1.Semantic proximity Read ↗

The toposiomerase IIIalpha-RMI1-RMI2 complex orients human Bloom’s syndrome helicase for efficient disruption of D-loopsSemantic proximity Read ↗

Structure and cellular roles of the RMI core complex from the bloom syndrome dissolvasome.Semantic proximity Read ↗

The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchangesSemantic proximity Read ↗

A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75.Semantic proximity Read ↗

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