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Article

Human topoisomerase IIIalpha is a single-stranded DNA decatenase that is stimulated by BLM and RMI1.

The Journal of biological chemistry - 9 Jul 2010

Yang Jay, Bachrati Csanad Z, Ou Jiongwen, Hickson Ian D, Brown Grant W

Abstract excerpt

Human topoisomerase IIIalpha is a type IA DNA topoisomerase that functions with BLM and RMI1 to resolve DNA replication and recombination intermediates. BLM, human topoisomerase IIIalpha, and RMI1 catalyze the dissolution of double Holliday junctions into noncrossover products via a strand-passage mechanism. We generated single-stranded catenanes that resemble the proposed dissolution intermediate recognized by...

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Share to Carrier Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Topoisomerases, Type I

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Source

Open in PubMed Open full text

Identifiers

PMID: 20445207
DOI: 10.1074/jbc.M110.123216
PMCID: PMC2898442

Genes

RMI1
BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Human topoisomerase IIIalpha is a single-stranded DNA decatenase that is stimulated by BLM and RMI1.PMID 20445207Read ↗

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