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Article

Topoisomerase 3alpha and RMI1 suppress somatic crossovers and are essential for resolution of meiotic recombination intermediates in Arabidopsis thaliana.

PLoS genetics - 1 Dec 2008

Hartung Frank, Suer Stefanie, Knoll Alexander, Wurz-Wildersinn Rebecca, Puchta Holger

Abstract excerpt

Topoisomerases are enzymes with crucial functions in DNA metabolism. They are ubiquitously present in prokaryotes and eukaryotes and modify the steady-state level of DNA supercoiling. Biochemical analyses indicate that Topoisomerase 3alpha (TOP3alpha) functions together with a RecQ DNA helicase and a third partner, RMI1/BLAP75, in the resolution step of homologous recombination in a process called Holliday...

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Source

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Identifiers

PMID: 19096507
DOI: 10.1371/journal.pgen.1000285
PMCID: PMC2588661

Genes

RMI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Topoisomerase 3alpha and RMI1 suppress somatic crossovers and are essential for resolution of meiotic recombination intermediates in Arabidopsis thaliana.PMID 19096507Read ↗

Different functional roles of RTR complex factors in DNA repair and meiosis in Arabidopsis and tomato.Semantic proximity Read ↗

RMI1 and TOP3α limit meiotic CO formation through their C-terminal domains.Semantic proximity Read ↗

Multiple mechanisms limit meiotic crossovers: TOP3α and two BLM homologs antagonize crossovers in parallel to FANCM.Semantic proximity Read ↗

The Arabidopsis BLAP75/Rmi1 homologue plays crucial roles in meiotic double-strand break repair.Semantic proximity Read ↗

The role of DNA topoisomerase 1α (AtTOP1α) in regulating arabidopsis meiotic recombination and chromosome segregation.Semantic proximity Read ↗

The Role of Topoisomerase II in DNA Repair and Recombination in Arabidopsis thaliana.Semantic proximity Read ↗

The Arabidopsis ROCK-N-ROLLERS gene encodes a homolog of the yeast ATP-dependent DNA helicase MER3 and is required for normal meiotic crossover formation.Semantic proximity Read ↗

Two closely related RecQ helicases have antagonistic roles in homologous recombination and DNA repair in Arabidopsis thaliana.Semantic proximity Read ↗

Meiotic Chromosome Association 1 Interacts with TOP3α and Regulates Meiotic Recombination in Rice.Semantic proximity Read ↗

The atspo11-1 mutation rescues atxrcc3 meiotic chromosome fragmentation.Semantic proximity Read ↗

Characterization of Brca2-deficient plants excludes the role of NHEJ and SSA in the meiotic chromosomal defect phenotype.Semantic proximity Read ↗

Replication protein A (AtRPA1a) is required for class I crossover formation but is dispensable for meiotic DNA break repair.Semantic proximity Read ↗

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