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Article

A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75.

The Journal of biological chemistry - 19 May 2006

Raynard Steven, Bussen Wendy, Sung Patrick

Abstract excerpt

Bloom syndrome (BS), an autosomal recessive disorder, is marked by a high incidence of cancer early in life. Cells derived from BS patients are unstable genetically and exhibit frequent sister chromatid exchanges, reflective of homologous recombination (HR) deregulation. BLM, the RecQ-like helicase mutated in BS, is found in several cellular protein complexes, all of which contain topoisomerase IIIalpha (Topo...

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Share to Adenosine Triphosphatases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Topoisomerases, Type I

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Source

Identifiers

PMID: 16595695
DOI: 10.1074/jbc.C600051200

Genes

BLM
WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75.PMID 16595695Read ↗

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