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Article

Attenuating functions of the C terminus of lambda integrase.

Journal of molecular biology - 6 Dec 2002

Tekle Michael, Warren David J, Biswas Tapan, Ellenberger Tom, Landy Arthur, Nunes-Düby Simone E

Abstract excerpt

The tyrosine family site-specific recombinases, in contrast to the related type I topoisomerases, which act as monomers on a single DNA molecule, rely on multi-protein complexes to synapse partner DNAs and coordinate two sequential strand exchanges involving four nicking-closing reactions. Here, we analyze three mutants of the catalytic domain of lambda integrase (Int), A241V, I353M and W350ter that are defective...

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Share to Bacteriophage lambda
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Share to DNA Topoisomerases, Type I

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12460568
DOI: 10.1016/s0022-2836(02)01108-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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