Article
Glucocorticoid receptor gene polymorphisms are associated with reduced first-phase glucose-stimulated insulin secretion and disposition index in women, but not in men.
Diabetic medicine : a journal of the British Diabetic Association - 1 Aug 2012
van Raalte D H, van Leeuwen N, Simonis-Bik A M, Nijpels G, van Haeften T W, Schafer S A, Boomsma D I, Kramer M H H, J Heine R, Maassen J A, Staiger H, Machicao F, Häring H-U, Slagboom P E, Willemsen G, de Geus E J, Dekker J M, Fritsche A, Eekhoff E M, Diamant M, 't Hart L M
Abstract excerpt
AIM: Glucocorticoids are efficacious anti-inflammatory agents, but, in susceptible individuals, these drugs may induce glucose intolerance and diabetes by affecting β-cell function and insulin sensitivity. We assessed whether polymorphisms in the glucocorticoid receptor gene NR3C1 associate with measures of β-cell function and insulin sensitivity derived from hyperglycaemic clamps in subjects with normal or...
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