Article
Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced beta-cell function in non-diabetic subjects.
BMC medical genetics - 14 Aug 2009
Weyrich Peter, Staiger Harald, Stancáková Alena, Schäfer Silke A, Kirchhoff Kerstin, Ullrich Susanne, Ranta Felicia, Gallwitz Baptist, Stefan Norbert, Machicao Fausto, Kuusisto Johanna, Laakso Markku, Fritsche Andreas, Häring Hans-Ulrich
Abstract excerpt
BACKGROUND: Neuron-derived orphan receptor (Nor) 1, nuclear receptor (Nur) 77, and nuclear receptor-related protein (Nurr) 1 constitute the NR4A family of orphan nuclear receptors which were recently found to modulate hepatic glucose production, insulin signalling in adipocytes, and oxidative metabolism in skeletal muscle. In this study, we assessed whether common genetic variation within the NR4A3 locus,...
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