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Article

HPA axis dysregulation, NR3C1 polymorphisms and glucocorticoid receptor isoforms imbalance in metabolic syndrome.

Diabetes/metabolism research and reviews - 1 Mar 2017

Martins Clarissa Silva, Elias Daniel, Colli Leandro Machado, Couri Carlos Eduardo, Souza Manoel Carlos L A, Moreira Ayrton C, Foss Milton C, Elias Lucila L K, de Castro Margaret

Abstract excerpt

CONTEXT: Metabolic syndrome (MetS) shares several similarities with hypercortisolism. OBJECTIVES: To evaluate hypothalamic-pituitary-adrenal (HPA) axis sensitivity to dexamethasone (DEX), NR3C1 single nucleotide polymorphisms (SNPs), and expression of glucocorticoid receptor (GR) isoforms and cytokines in peripheral immune cells of MetS patients and controls. DESIGN: Prospective study with 40 MetS patients and 40...

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Identifiers

PMID: 27507764
DOI: 10.1002/dmrr.2842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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