Article
Pathophysiology of Glucocorticoid Signaling.
Annales d'endocrinologie - 1 Jun 2018
Vitellius Géraldine, Trabado Séverine, Bouligand Jérôme, Delemer Brigitte, Lombès Marc
Abstract excerpt
Glucocorticoids (GC), such as cortisol or dexamethasone, control various physiological functions, notably those involved in development, metabolism, inflammatory processes and stress, and exert most of their effects upon binding to the glucocorticoid receptor (GR, encoded by NR3C1 gene). GC signaling follows several consecutive steps leading to target gene transactivation, including ligand binding, nuclear...
Topics
- Cushing Syndrome
- Genetic Predisposition to Disease
- Glucocorticoids
- Humans
- Hypothalamo-Hypophyseal System
- Metabolism, Inborn Errors
- Mutation
- Pituitary-Adrenal System
- Polymorphism, Genetic
- Receptors, Glucocorticoid
- Signal Transduction