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Article

Association of glucocorticoid receptor polymorphism A3669G with decreased risk of developing diabetes in patients with Cushing's syndrome.

European journal of endocrinology - 1 Jan 2012

Trementino Laura, Appolloni Gloria, Concettoni Carolina, Cardinaletti Marina, Boscaro Marco, Arnaldi Giorgio

Abstract excerpt

OBJECTIVE: Glucocorticoid receptor (GR) polymorphisms alter glucocorticoid (GC) sensitivity and have been associated with altered metabolic profiles. We evaluate the prevalence of the four GR (NR3C1) polymorphisms BclI, N363S, ER22/23EK, and A3669G in patients with Cushing's syndrome (CS) compared with healthy controls (HC) and we investigate their role in the development of metabolic abnormalities in patients...

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Identifiers

PMID: 22048965
DOI: 10.1530/EJE-11-0722

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