Article
BClI polymorphism of the glucocorticoid receptor gene is associated with increased obesity, impaired glucose metabolism and dyslipidaemia in patients with Addison's disease.
Clinical endocrinology - 1 Dec 2012
Giordano Roberta, Marzotti Stefania, Berardelli Rita, Karamouzis Ioannis, Brozzetti Annalisa, D'Angelo Valentina, Mengozzi Giulio, Mandrile Giorgia, Giachino Daniela, Migliaretti Giuseppe, Bini Vittorio, Falorni Alberto, Ghigo Ezio, Arvat Emanuela
Abstract excerpt
OBJECT: Although glucocorticoids are essential for health, several studies have shown that glucocorticoids replacement in Addison's disease might be involved in anthropometric and metabolic impairment, with increased cardiovascular risk, namely if conventional doses are used. As the effects of glucocorticoids are mediated by the glucocorticoid receptor, encoded by NR3C1 gene, different polymorphisms in the NR3C1...
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