Article
Genetic glucocorticoid receptor variants differ between ethnic groups but do not explain variation in age of diabetes onset, metabolic and inflammation parameters in patients with type 2 diabetes.
Frontiers in endocrinology - 1 Jan 2023
Ahdi Mohamed, Gerards Maaike C, Smits Paul H M, Meesters Eelco W, Brandjes Dees P M, Nieuwdorp Max, Gerdes Victor E A
Abstract excerpt
Aims: The effect of excess glucocorticoid receptor (GR) stimulation through glucocorticoid medication or cortisol on glucose metabolism is well established. There are genetic GR variants that result in increased or decreased GR stimulation. We aimed to determine the prevalence of genetic GR variants in different ethnic groups in a cohort of patients with type 2 diabetes, and we aimed to determine their...
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