Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Improving pedigree-based linkage analysis by estimating coancestry among families.

Statistical applications in genetics and molecular biology - 6 Jan 2012

Glazner Chris, Thompson Elizabeth Alison

Abstract excerpt

We present a method for improving the power of linkage analysis by detecting chromosome segments shared identical by descent (IBD) by individuals not known to be related. Existing Markov chain Monte Carlo methods sample descent patterns on pedigrees conditional on observed marker data. These patterns can be stored as IBD graphs, which express shared ancestry only, rather than specific family relationships. A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Computer Simulation
Share to Family

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Linkage

Share to Genotype

Share to Lod Score

Share to Models, Genetic

Share to Pedigree

Source

Open in PubMed Open full text

Identifiers

PMID: 22499699
DOI: 10.2202/1544-6115.1718
PMCID: PMC3368982

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Improving pedigree-based linkage analysis by estimating coancestry among families.PMID 22499699Read ↗

A method for detecting IBD regions simultaneously in multiple individuals--with applications to disease genetics.Semantic proximity Read ↗

Identifying the phenotypic effect of rare variants by including between-pedigree coancestry in variance components linkage analysisSemantic proximity Read ↗

Relatedness mapping and tracts of relatedness for genome-wide data in the presence of linkage disequilibrium.Semantic proximity Read ↗

Inferring coancestry in population samples in the presence of linkage disequilibrium.Semantic proximity Read ↗

Calculation of IBD probabilities with dense SNP or sequence data.Semantic proximity Read ↗

Pedigree generation for analysis of genetic linkage and association.Semantic proximity Read ↗

The probabilistic determination of identity-by-descent sharing for pairs of relatives from pedigrees.Semantic proximity Read ↗

Coordinated conditional simulation with SLINK and SUP of many markers linked or associated to a trait in large pedigrees.Semantic proximity Read ↗

Estimating the power of variance component linkage analysis in large pedigrees.Semantic proximity Read ↗

Extending admixture mapping to nuclear pedigrees: application to sarcoidosis.Semantic proximity Read ↗

Power of multipoint identity-by-descent methods to detect linkage using variance component models.Semantic proximity Read ↗

Efficient genome ancestry inference in complex pedigrees with inbreeding.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.