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Article

Extending admixture mapping to nuclear pedigrees: application to sarcoidosis.

Genetic epidemiology - 1 Apr 2013

McKeigue Paul M, Colombo Marco, Agakov Felix, Datta Indrani, Levin Albert, Favro David, Gray-Montgomery Courtney, Iannuzzi Michael C, Rybicki Benjamin A

Abstract excerpt

We describe statistical methods that extend the application of admixture mapping from unrelated individuals to nuclear pedigrees, allowing existing pedigree-based collections to be fully exploited. Computational challenges have been overcome by developing a fast algorithm that exploits the factorial structure of the underlying model of ancestry transitions. This has been implemented as an extension of the program...

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PMID: 23371909
DOI: 10.1002/gepi.21710
PMCID: PMC3756835

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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