Power of multipoint identity-by-descent methods to detect linkage using variance component models.

Abstract excerpt

Multipoint linkage analysis gives increased power over single-point analysis to detect linkage for quantitative trait loci (QTL). Besides increased power, the use of multipoint methods makes it possible to estimate not only the location but also the magnitude of the QTL. Currently, two methods are commonly used for calculating multipoint identity-by-descent (IBD) allele-sharing estimates for pedigrees of moderate...

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