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Article

Association of CRHR1 and CRHR2 with major depressive disorder and panic disorder in a Japanese population.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jun 2012

Ishitobi Yoshinobu, Nakayama Shinya, Yamaguchi Kana, Kanehisa Masayuki, Higuma Haruka, Maruyama Yoshihiro, Ninomiya Taiga, Okamoto Shizuko, Tanaka Yoshihiro, Tsuru Jusen, Hanada Hiroaki, Isogawa Koichi, Akiyoshi Jotaro

Abstract excerpt

Major depressive disorder (MDD) and panic disorder (PD) are common and disabling medical disorders with stress and genetic components. Dysregulation of the stress response of the hypothalamic-pituitary-adrenal axis, including the corticotrophin-releasing hormone (CRH) signaling via primary receptors (CRHR1 and CRHR2), is considered to play a major role for onset and recurrence in MDD and PD. To confirm the...

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Source

Identifiers

PMID: 22467522
DOI: 10.1002/ajmg.b.32046

Genes

CRHR1
CRHR2
CRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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