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Article

Interaction between CRHR1 and BDNF genes increases the risk of recurrent major depressive disorder in Chinese population.

PloS one - 1 Jan 2011

Xiao Zheman, Liu Wanhong, Gao Kai, Wan Qirong, Yang Can, Wang Huiling, Wang Xiaoping, Wang Gaohua, Liu Zhongchun

Abstract excerpt

BACKGROUND: An important etiological hypothesis about depression is stress has neurotoxic effects that damage the hippocampal cells. Corticotropin-releasing hormone (CRH) regulates brain-derived neurotrophic factor (BDNF) expression through influencing cAMP and Ca2+ signaling pathways during the course. The aim of this study is to examine the single and combined effects of CRH receptor 1 (CRHR1) and BDNF genes in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22194899
DOI: 10.1371/journal.pone.0028733
PMCID: PMC3237493

Genes

BDNF
CRHR1
CRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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