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Article

CRHR1 promoter hypomethylation: An epigenetic readout of panic disorder?

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Apr 2017

Schartner Christoph, Ziegler Christiane, Schiele Miriam A, Kollert Leonie, Weber Heike, Zwanzger Peter, Arolt Volker, Pauli Paul, Deckert Jürgen, Reif Andreas, Domschke Katharina

Abstract excerpt

The corticotropin releasing hormone receptor 1 (CRHR1) is crucially involved in the hypothalamic-pituitary-adrenal axis and thus a major regulator of the stress response. CRHR1 gene variation is associated with several mental disorders including anxiety disorders. Studies in rodents have demonstrated epigenetic regulation of CRHR1 gene expression to moderate response to stressful environment. In the present...

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PMID: 28233670
DOI: 10.1016/j.euroneuro.2017.01.005

Genes

CRHR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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