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Article

Comorbidity of Novel CRHR2 Gene Variants in Type 2 Diabetes and Depression.

International journal of molecular sciences - 29 Aug 2022

Amin Mutaz, Ott Jurg, Gordon Derek, Wu Rongling, Postolache Teodor T, Vergare Michael, Gragnoli Claudia

Abstract excerpt

The corticotropin-releasing hormone receptor 2 (CRHR2) gene encodes CRHR2, contributing to the hypothalamic-pituitary-adrenal stress response and to hyperglycemia and insulin resistance. CRHR2-/- mice are hypersensitive to stress, and the CRHR2 locus has been linked to type 2 diabetes and depression. While CRHR2 variants confer risk for mood disorders, MDD, and type 2 diabetes, they have not been investigated in...

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Share to Comorbidity
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Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Linkage Disequilibrium

Share to Polymorphism, Single Nucleotide

Share to Receptors, Corticotropin-Releasing Hormone

Source

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Identifiers

PMID: 36077219
DOI: 10.3390/ijms23179819
PMCID: PMC9456299

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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