Article
Allelic variation in CRHR1 predisposes to panic disorder: evidence for biased fear processing.
Molecular psychiatry - 1 Jun 2016
Weber H, Richter J, Straube B, Lueken U, Domschke K, Schartner C, Klauke B, Baumann C, Pané-Farré C, Jacob C P, Scholz C-J, Zwanzger P, Lang T, Fehm L, Jansen A, Konrad C, Fydrich T, Wittmann A, Pfleiderer B, Ströhle A, Gerlach A L, Alpers G W, Arolt V, Pauli P, Wittchen H-U, Kent L, Hamm A, Kircher T, Deckert J, Reif A
Abstract excerpt
Corticotropin-releasing hormone (CRH) is a major regulator of the hypothalamic-pituitary-adrenal axis. Binding to its receptor CRHR1 triggers the downstream release of the stress response-regulating hormone cortisol. Biochemical, behavioral and genetic studies revealed CRHR1 as a possible candidate gene for mood and anxiety disorders. Here we aimed to evaluate CRHR1 as a risk factor for panic disorder (PD)....
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