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Article

Effects of corticotropin-releasing hormone receptor 1 SNPs on major depressive disorder are influenced by sex and smoking status.

Journal of affective disorders - 15 Nov 2016

da Silva Bruna S, Rovaris Diego L, Schuch Jaqueline B, Mota Nina R, Cupertino Renata B, Aroche Angelita P, Bertuzzi Guilherme P, Karam Rafael G, Vitola Eduardo S, Tovo-Rodrigues Luciana, Grevet Eugenio H, Bau Claiton H D

Abstract excerpt

BACKGROUND: The corticotropin-releasing hormone receptor 1 (CRHR1) gene has been repeatedly implicated in Major Depressive Disorder (MDD) in humans and animal models; however, the findings are not absolutely convergent. Since recent evidence from genome-wide association studies suggests that narrowing the phenotypic heterogeneity may be crucial in genetic studies of MDD, the aim of this study was to evaluate the...

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Source

Identifiers

PMID: 27544317
DOI: 10.1016/j.jad.2016.08.008

Genes

CRHR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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