Article
Phosphatidylinositol-3-kinase pathway mutations are common in breast columnar cell lesions.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2012
Troxell Megan L, Brunner Alayne L, Neff Tanaya, Warrick Andrea, Beadling Carol, Montgomery Kelli, Zhu Shirley, Corless Christopher L, West Robert B
Abstract excerpt
The phosphatidylinositol-3-kinase pathway is one of the most commonly mutated pathways in invasive breast carcinoma, with PIK3CA mutations in ∼25% of invasive carcinomas, and AKT1 mutations in up to 5%. Ductal carcinoma in situ, and benign papillomas harbor similar mutations. However, activating point mutations in breast columnar cell lesions have been infrequently studied. Twenty-three breast resection specimens...
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