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Article

PI3K pathway activation in breast cancer is associated with the basal-like phenotype and cancer-specific mortality.

International journal of cancer - 1 Mar 2010

López-Knowles Elena, O'Toole Sandra A, McNeil Catriona M, Millar Ewan K A, Qiu Min R, Crea Paul, Daly Roger J, Musgrove Elizabeth A, Sutherland Robert L

Abstract excerpt

Breast cancer is a common malignancy with current biological therapies tailored to steroid hormone (ER, PR) and HER2 receptor status. Understanding the biological basis of resistance to current targeted therapies and the identification of new potential therapeutic targets is an ongoing challenge. The PI3K pathway is altered in a high proportion of breast cancers and may contribute to therapeutic resistance. We...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 19685490
DOI: 10.1002/ijc.24831

Genes

PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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