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Article

Oncogenic PIK3CA mutations in lobular breast cancer progression.

Genes, chromosomes & cancer - 1 Jan 2013

Christgen Matthias, Noskowicz Monika, Schipper Elisa, Christgen Henriette, Heil Charlotte, Krech Till, Länger Florian, Kreipe Hans, Lehmann Ulrich

Abstract excerpt

Infiltrating lobular breast cancer (ILBC) is a tumor-biologically distinct breast cancer subtype. A high frequency of oncogenic PIK3CA mutations has been reported in ILBC, which may allow for targeted therapy with newly developed PI3K inhibitors. This is of particular clinical relevance for ILBC patients, who have failed to respond to current treatment regimes and suffer from tumor recurrence or dissemination. In...

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PMID: 22997091
DOI: 10.1002/gcc.22007

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