Article
Mucinous breast carcinomas lack PIK3CA and AKT1 mutations.
Human pathology - 1 Dec 2012
Kehr Elizabeth L, Jorns Julie M, Ang Daphne, Warrick Andrea, Neff Tanaya, Degnin Michelle, Lewis Rebecca, Beadling Carol, Corless Christopher L, Troxell Megan L
Abstract excerpt
Activating point mutations in the phosphatidylinositol-3-kinase catalytic subunit (PIK3CA) are among the most common molecular defects in invasive breast cancer. Point mutations in the downstream kinase AKT1 are seen in a minority of carcinomas. These mutations are found preferentially in estrogen receptor-positive and Her2-positive breast carcinomas; however, special morphologic types of breast cancer have not...
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