Activating PIK3CA Mutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer.

doi:10.1074/mcp.M115.049783

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Activating PIK3CA Mutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer.

Molecular & cellular proteomics : MCP - 1 Jul 2015

Young Christian D, Zimmerman Lisa J, Hoshino Daisuke, Formisano Luigi, Hanker Ariella B, Gatza Michael L, Morrison Meghan M, Moore Preston D, Whitwell Corbin A, Dave Bhuvanesh, Stricker Thomas, Bhola Neil E, Silva Grace O, Patel Premal, Brantley-Sieders Dana M, Levin Maren, Horiates Marina, Palma Norma A, Wang Kai, Stephens Philip J, Perou Charles M, Weaver Alissa M, O'Shaughnessy Joyce A, Chang Jenny C, Park Ben Ho, Liebler Daniel C, Cook Rebecca S, Arteaga Carlos L

Abstract excerpt

Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of phosphoinositide 3-kinase (PI3K) have been shown to transform human mammary epithelial cells (MECs). These mutations are present in all breast cancer subtypes, including basal-like breast cancer (BLBC). Using liquid chromatography-tandem mass spectrometry (LC-MS/MS), we identified 72 protein expression changes in human basal-like MECs with...

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PMID: 25953087
DOI: 10.1074/mcp.M115.049783
PMCID: PMC4587316

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EGFR

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