Article
PIK3CA mutations mostly begin to develop in ductal carcinoma of the breast.
Experimental and molecular pathology - 1 Feb 2010
Li Hua, Zhu Rong, Wang Lei, Zhu Tengfang, Li Qiong, Chen Qi, Wang Hong, Zhu Hongguang
Abstract excerpt
Somatic mutations of PIK3CA are found in 20% to 40% of invasive breast cancers. To investigate the frequency of PIK3CA mutations in the intraductal proliferative lesions of the breast, which are precursor lesions for invasive carcinoma, we analyzed 125 intraductal proliferative lesions and 108 invasive breast cancer tissues for PIK3CA mutations in this study. Target cells were precisely isolated using a laser...
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