Article
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.
Cancer research - 1 Aug 2008
Stemke-Hale Katherine, Gonzalez-Angulo Ana Maria, Lluch Ana, Neve Richard M, Kuo Wen-Lin, Davies Michael, Carey Mark, Hu Zhi, Guan Yinghui, Sahin Aysegul, Symmans W Fraser, Pusztai Lajos, Nolden Laura K, Horlings Hugo, Berns Katrien, Hung Mien-Chie, van de Vijver Marc J, Valero Vicente, Gray Joe W, Bernards René, Mills Gordon B, Hennessy Bryan T
Abstract excerpt
Phosphatidylinositol 3-kinase (PI3K)/AKT pathway aberrations are common in cancer. By applying mass spectroscopy-based sequencing and reverse-phase protein arrays to 547 human breast cancers and 41 cell lines, we determined the subtype specificity and signaling effects of PIK3CA, AKT, and PTEN mutations and the effects of PIK3CA mutations on responsiveness to PI3K inhibition in vitro and on outcome after adjuvant...
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