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Article

High prevalence of PIK3CA/AKT pathway mutations in papillary neoplasms of the breast.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 2010

Troxell Megan L, Levine Judith, Beadling Carol, Warrick Andrea, Dunlap Jennifer, Presnell Ajia, Patterson Janice, Shukla Arielle, Olson Neal R, Heinrich Michael C, Corless Christopher L

Abstract excerpt

Papillary lesions of the breast have an uncertain relationship to the histogenesis of breast carcinoma, and are thus diagnostically and managerially challenging. Molecular genetic studies have provided evidence that ductal carcinoma in situ and even atypical ductal hyperplasia are precursors of invasive carcinoma. However, papillary lesions have been seldom studied. We screened papillary breast neoplasms for...

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Topics

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Share to Breast Neoplasms
Share to Carcinoma, Papillary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

Share to DNA Mutational Analysis

Share to Phosphatidylinositol 3-Kinases

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Share to Proto-Oncogene Proteins c-akt

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Source

Identifiers

PMID: 19898424
DOI: 10.1038/modpathol.2009.142

Genes

AKT1
NRAS
AKT2
BRAF
EGFR
ERBB2
HRAS
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High prevalence of PIK3CA/AKT pathway mutations in papillary neoplasms of the breast.PMID 19898424Read ↗

Comprehensive profiling of the mutational landscape of hidradenoma papilliferum validates key role of alterations in the PI3K/AKT pathway alterationsSemantic proximity Read ↗

Frequent phosphatidylinositol-3-kinase mutations in proliferative breast lesions.Semantic proximity Read ↗

Frequent PIK3CA-activating mutations in hidradenoma papilliferums.Semantic proximity Read ↗

Intraductal Papillary Mucinous Neoplasms of Minor Salivary Glands With AKT1 p.Glu17Lys Mutation.Semantic proximity Read ↗

PIK3CA and AKT1 mutations in hidradenoma papilliferum.Semantic proximity Read ↗

Frequent PIK3CA activating mutations in nipple adenomas.Semantic proximity Read ↗

AKT1 Mutations in Peripheral Bronchiolar Papilloma: Glandular Papilloma and Mixed Squamous Cell and Glandular Papilloma Is Distinct From Bronchiolar Adenoma.Semantic proximity Read ↗

Tubular, lactating, and ductal adenomas are devoid of MED12 Exon2 mutations, and ductal adenomas show recurrent mutations in GNAS and the PI3K-AKT pathway.Semantic proximity Read ↗

The genetic architecture of breast papillary lesions as a predictor of progression to carcinomaSemantic proximity Read ↗

Mutations in genes encoding PI3K-AKT and MAPK signaling define anogenital papillary hidradenoma.Semantic proximity Read ↗

PIK3CA mutations mostly begin to develop in ductal carcinoma of the breast.Semantic proximity Read ↗

Mucinous breast carcinomas lack PIK3CA and AKT1 mutations.Semantic proximity Read ↗

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