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Article

Frequent phosphatidylinositol-3-kinase mutations in proliferative breast lesions.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2014

Ang Daphne C, Warrick Andrea L, Shilling Amy, Beadling Carol, Corless Christopher L, Troxell Megan L

Abstract excerpt

The phosphatidylinositol-3-kinase pathway is one of the most commonly altered molecular pathways in invasive breast carcinoma, with phosphatidylinositol-3-kinase catalytic subunit (PIK3CA) mutations in 25% of invasive carcinomas. Ductal carcinoma in situ (DCIS), benign papillomas, and small numbers of columnar cell lesions harbor an analogous spectrum of PIK3CA and AKT1 mutations, yet there is little data on...

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Share to Breast Neoplasms
Share to Carcinoma, Intraductal, Noninfiltrating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Class I Phosphatidylinositol 3-Kinases

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Source

Identifiers

PMID: 24186142
DOI: 10.1038/modpathol.2013.197

Genes

AKT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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