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Article

Mutational analysis of PI3K/AKT signaling pathway in tamoxifen exemestane adjuvant multinational pathology study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Sept 2014

Sabine Vicky S, Crozier Cheryl, Brookes Cassandra L, Drake Camilla, Piper Tammy, van de Velde Cornelis J H, Hasenburg Annette, Kieback Dirk G, Markopoulos Christos, Dirix Luc, Seynaeve Caroline, Rea Daniel W, Bartlett John M S

Abstract excerpt

PURPOSE: Deregulation of key PI3K/AKT pathway genes may contribute to endocrine resistance in breast cancer (BC). PIK3CA is the most frequently mutated gene in luminal BC (35%); however, the effect of mutations in helical versus kinase domains remains controversial. We hypothesize that improved outcomes occur in patients with estrogen receptor–positive (ER positive) BC receiving endocrine therapy and possessing...

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Identifiers

PMID: 25071141
DOI: 10.1200/JCO.2013.53.8272

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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