Article
Specific Ki-ras codon 61 mutations may determine the development of urethan-induced mouse lung adenomas or adenocarcinomas.
Molecular carcinogenesis - 1 Jan 1990
Nuzum E O, Malkinson A M, Beer D G
Abstract excerpt
In A/J strain mice, the carcinogen urethan induces lung adenomas and adenocarcinomas that contain Ki-ras-activating mutations primarily in codon 61. These mutations affect the middle adenine in codon 61 resulting in the substitution of either arginine (AT----GC transition) or leucine (AT----TA tr...
Topics
- Adenocarcinoma
- Adenoma
- Animals
- Codon
- Gene Expression
- Lung Neoplasms
- Mice
- Mice, Inbred A
- Mutation
- Polymerase Chain Reaction
- Proto-Oncogene Proteins p21(ras)
- RNA, Messenger