Telomerase activation and p53 mutations in urethane-induced A/J mouse lung tumor development.

doi:10.1093/carcin/22.5.751

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Article

Telomerase activation and p53 mutations in urethane-induced A/J mouse lung tumor development.

Carcinogenesis - 1 May 2001

Ohno J, Horio Y, Sekido Y, Hasegawa Y, Takahashi M, Nishizawa J, Saito H, Ishikawa F, Shimokata K

Abstract excerpt

The mouse telomerase holoenzyme, which synthesizes telomeric DNA de novo, is a ribonucleoprotein complex that includes the mouse telomerase RNA component (mTERC), mouse telomerase-associated protein (mTEP1) and mouse telomerase reverse transcriptase (mTERT). To determine the role of telomerase in urethane-induced lung tumorigenesis in A/J mice we examined telomerase activity and the expression of each telomerase...

Topics

Animals
Carcinogens
Enzyme Activation
Genes, p53
Lung Neoplasms
Mice
Mice, Inbred Strains
Mutation
RNA, Messenger
Reverse Transcriptase Polymerase Chain Reaction
Telomerase
Urethane

Source

Open in PubMed

Identifiers

PMID: 11323394
DOI: 10.1093/carcin/22.5.751

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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