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Article

Telomerase activation and p53 mutations in urethane-induced A/J mouse lung tumor development.

Carcinogenesis - 1 May 2001

Ohno J, Horio Y, Sekido Y, Hasegawa Y, Takahashi M, Nishizawa J, Saito H, Ishikawa F, Shimokata K

Abstract excerpt

The mouse telomerase holoenzyme, which synthesizes telomeric DNA de novo, is a ribonucleoprotein complex that includes the mouse telomerase RNA component (mTERC), mouse telomerase-associated protein (mTEP1) and mouse telomerase reverse transcriptase (mTERT). To determine the role of telomerase in urethane-induced lung tumorigenesis in A/J mice we examined telomerase activity and the expression of each telomerase...

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Identifiers

PMID: 11323394
DOI: 10.1093/carcin/22.5.751

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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