Article
Heterozygous inactivation of TGF-beta1 increases the susceptibility to chemically induced mouse lung tumorigenesis independently of mutational activation of K-ras.
Toxicology letters - 15 Sept 2001
McKenna I M, Ramakrishna G, Diwan B A, Kang Y, Shiao Y H, Wakefield L M, Powell D A, Anderson L M, Jakowlew S B
Abstract excerpt
Mice heterozygous for deletion of the transforming growth factor beta1 (TGF-beta1) gene show an enhanced rate of lung tumorigenesis following carcinogen treatment. Since the growth inhibitory activity of TGF-beta1 in epithelial cells is associated with K-ras p21, and K-ras mutations commonly occur in chemically-induced mouse lung tumors, we postulated that tumors in heterozygous TGF-beta1 mice might be more...
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