Article
Comparison of Ki-ras gene mutation among simultaneously occurring multiple urethan-induced lung tumors in individual mice.
Carcinogenesis - 1 May 1992
Ohmori H, Abe T, Hirano H, Murakami T, Katoh T, Gotoh S, Kido M, Kuroiwa A, Nomura T, Higashi K
Abstract excerpt
Mouse lung tumors were induced in C57BL/6J(female) x A/J(male) F1 mice by a single s.c. injection of urethan. About 6 months later, multiple small-sized lung tumors were detectable in almost all mice. After a further 6 months, some of these tumors became larger than the rest. We examined whether there were any mutational differences among multiple lung tumors in a single mouse. Direct DNA sequencing of a...
Topics
- Amino Acid Sequence
- Animals
- DNA, Neoplasm
- Exons
- Female
- Genes, ras
- Lung Neoplasms
- Male
- Mice
- Molecular Sequence Data
- Mutation
- Neoplasms, Multiple Primary