Article
Ki-ras and p53 mutations are early and late events, respectively, in urethane-induced pulmonary carcinogenesis in A/J mice.
Molecular carcinogenesis - 1 Dec 1996
Horio Y, Chen A, Rice P, Roth J A, Malkinson A M, Schrump D S
Abstract excerpt
In the A/J strain of mice, urethane (ethyl carbamate) induces lung hyperplasia, adenoma, and adenocarcinoma in a time-dependent manner. These distinct morphological stages may correlate with sequential molecular genetic changes in this mouse model. To test this hypothesis, we investigated the pre...
Topics
- Adenocarcinoma
- Adenoma
- Animals
- Base Sequence
- Carcinogens
- Disease Progression
- Exons
- Genes, p53
- Genes, ras
- Hyperplasia
- Lung Neoplasms
- Mice
- Mice, Inbred A
- Molecular Sequence Data
- Mutation
- Precancerous Conditions
- Time Factors
- Urethane