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Article

Ki-ras and p53 mutations are early and late events, respectively, in urethane-induced pulmonary carcinogenesis in A/J mice.

Molecular carcinogenesis - 1 Dec 1996

Horio Y, Chen A, Rice P, Roth J A, Malkinson A M, Schrump D S

Abstract excerpt

In the A/J strain of mice, urethane (ethyl carbamate) induces lung hyperplasia, adenoma, and adenocarcinoma in a time-dependent manner. These distinct morphological stages may correlate with sequential molecular genetic changes in this mouse model. To test this hypothesis, we investigated the presence of mutations involving Ki-ras and p53 in urethane-induced lung lesions in A/J mice at early and late stages of...

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PMID: 8989915
DOI: 10.1002/(SICI)1098-2744(199612)17:4<217::AID-MC5>3.0.CO;2-A

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