Article
Mouse pulmonary adenoma susceptibility 1 locus is an expression QTL modulating Kras-4A.
PLoS genetics - 1 Apr 2014
Dassano Alice, Colombo Francesca, Trincucci Gaia, Frullanti Elisa, Galvan Antonella, Pettinicchio Angela, De Cecco Loris, Borrego Andrea, Martinez Ibañez Olga Célia, Dragani Tommaso A, Manenti Giacomo
Abstract excerpt
Pulmonary adenoma susceptibility 1 (Pas1) is the major locus responsible for lung tumor susceptibility in mice; among the six genes mapping in this locus, Kras is considered the best candidate for Pas1 function although how it determines tumor susceptibility remains unknown. In an (A/J × C57BL/6)F4 intercross population treated with urethane to induce lung tumors, Pas1 not only modulated tumor susceptibility (LOD...
Topics
- Adenoma
- Alleles
- Animals
- Chromosome Mapping
- Female
- Genetic Predisposition to Disease
- Lung Neoplasms
- Male
- Mice
- Mice, Inbred C57BL
- Polymorphism, Single Nucleotide
- Proto-Oncogene Proteins p21(ras)
- Quantitative Trait Loci