Article
Additional evidence that the K-ras protooncogene is a candidate for the major mouse pulmonary adenoma susceptibility (Pas-1) gene.
Experimental lung research - 1 Jan 2000
Lin L, Festing M F, Devereux T R, Crist K A, Christiansen S C, Wang Y, Yang A, Svenson K, Paigen B, Malkinson A M, You M
Abstract excerpt
A locus for mouse pulmonary adenoma susceptibility, Pas-1, has been mapped on distal chromosome 6, where the K-ras gene is located. Allele-specific activation and expression of the K-ras allele from the susceptible parent has been observed in lung tumors from F1 hybrid mice. We report here genetic mapping of lung tumor susceptibility genes in urethane-treated A x B and B x A recombinant inbred (RI) mice using...
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