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Article

KIF21A-mediated axonal transport and selective endocytosis underlie the polarized targeting of NCKX2.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 Mar 2012

Lee Kyu-Hee, Lee Jae Sung, Lee Doyun, Seog Dae-Hyun, Lytton Jonathan, Ho Won-Kyung, Lee Suk-Ho

Abstract excerpt

We have previously shown that K(+)-dependent Na(+)/Ca(2+) exchanger (NCKX) is a major calcium clearance mechanism at the large axon terminals of central neurons, whereas their somata display little NCKX activity. We investigated mechanisms underlying the axonal polarization of NCKX2 in rat hippocampal neurons. We identified NCKX2 as the first neuron-specific cargo molecule of kinesin family member 21A (KIF21A)....

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Identifiers

PMID: 22442075
DOI: 10.1523/JNEUROSCI.6331-11.2012
PMCID: PMC6621231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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