Article

Regulation of the Na-K-2Cl cotransporter NKCC2 by ubiquitylation

2026-05-11

Abstract excerpt

NKCC2, localized to the apical membrane of thick ascending limb epithelial cells, is essential for renal salt handling and systemic electrolyte homeostasis. NKCC2 undergoes extensive ubiquitylation, with the E3 protein ligase Nedd4-2 implicated as a key regulator. However, progress has been limited by challenges expressing NKCC2 in mammalian cell lines, hindering mechanistic studies of NKCC2 ubiquitylation. Theref...

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Literature Corpus work: d2850a03-d4b1-56b4-9a4f-7392012bea72
DOI: 10.64898/2026.05.07.723577

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