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Article

Pincher, a pinocytic chaperone for nerve growth factor/TrkA signaling endosomes.

The Journal of cell biology - 13 May 2002

Shao Yufang, Akmentin Wendy, Toledo-Aral Juan Jose, Rosenbaum Julie, Valdez Gregorio, Cabot John B, Hilbush Brian S, Halegoua Simon

Abstract excerpt

A central tenet of nerve growth factor (NGF) action that is poorly understood is its ability to mediate cytoplasmic signaling, through its receptor TrkA, that is initiated at the nerve terminal and conveyed to the soma. We identified an NGF-induced protein that we termed Pincher (pinocytic chaperone) that mediates endocytosis and trafficking of NGF and its receptor TrkA. In PC12 cells, overexpression of Pincher...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12011113
DOI: 10.1083/jcb.200201063
PMCID: PMC2173850

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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