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Article

Transient receptor potential canonical 5 channels activate Ca2+/calmodulin kinase Igamma to promote axon formation in hippocampal neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 5 Aug 2009

Davare Monika A, Fortin Dale A, Saneyoshi Takeo, Nygaard Sean, Kaech Stefanie, Banker Gary, Soderling Thomas R, Wayman Gary A

Abstract excerpt

Functionality of neurons is dependent on their compartmentalized polarization of dendrites and an axon. The rapid and selective outgrowth of one neurite, relative to the others, to form the axon is critical in initiating neuronal polarity. Axonogenesis is regulated in part by an optimal intracellular calcium concentration. Our investigation of Ca(2+)-signaling pathways involved in axon formation using cultured...

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Source

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Identifiers

PMID: 19657032
DOI: 10.1523/JNEUROSCI.1544-09.2009
PMCID: PMC2763510

Genes

TRPC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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