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Article

An ankyrinG-binding motif is necessary and sufficient for targeting Nav1.6 sodium channels to axon initial segments and nodes of Ranvier.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 23 May 2012

Gasser Andreas, Ho Tammy Szu-Yu, Cheng Xiaoyang, Chang Kae-Jiun, Waxman Stephen G, Rasband Matthew N, Dib-Hajj Sulayman D

Abstract excerpt

Neurons are highly polarized cells with functionally distinct axonal and somatodendritic compartments. Voltage-gated sodium channels Na(v)1.2 and Na(v)1.6 are highly enriched at axon initial segments (AISs) and nodes of Ranvier, where they are necessary for generation and propagation of action potentials. Previous studies using reporter proteins in unmyelinated cultured neurons suggest that an ankyrinG-binding...

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Identifiers

PMID: 22623668
DOI: 10.1523/JNEUROSCI.5434-11.2012
PMCID: PMC3413458

Genes

CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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