Article
Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules.
The Journal of cell biology - 5 Mar 2001
Verhey K J, Meyer D, Deehan R, Blenis J, Schnapp B J, Rapoport T A, Margolis B
Abstract excerpt
The cargo that the molecular motor kinesin moves along microtubules has been elusive. We searched for binding partners of the COOH terminus of kinesin light chain, which contains tetratricopeptide repeat (TPR) motifs. Three proteins were found, the c-jun NH(2)-terminal kinase (JNK)-interacting proteins (JIPs) JIP-1, JIP-2, and JIP-3, which are scaffolding proteins for the JNK signaling pathway. Concentration of...
Topics
- Adaptor Proteins, Signal Transducing
- Amino Acid Motifs
- Amino Acid Sequence
- Animals
- Binding Sites
- Carrier Proteins
- Cell Line
- Kinesins
- LDL-Receptor Related Proteins
- MAP Kinase Kinase Kinases
- Mice