Article
KCC2 interacts with the dendritic cytoskeleton to promote spine development.
Neuron - 20 Dec 2007
Li Hong, Khirug Stanislav, Cai Chunlin, Ludwig Anastasia, Blaesse Peter, Kolikova Julia, Afzalov Ramil, Coleman Sarah K, Lauri Sari, Airaksinen Matti S, Keinänen Kari, Khiroug Leonard, Saarma Mart, Kaila Kai, Rivera Claudio
Abstract excerpt
The neuron-specific K-Cl cotransporter, KCC2, induces a developmental shift to render GABAergic transmission from depolarizing to hyperpolarizing. Now we demonstrate that KCC2, independently of its Cl(-) transport function, is a key factor in the maturation of dendritic spines. This morphogenic role of KCC2 in the development of excitatory synapses is mediated by structural interactions between KCC2 and the spine...
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