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Article

Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 25 Sept 2013

Chamma Ingrid, Heubl Martin, Chevy Quentin, Renner Marianne, Moutkine Imane, Eugène Emmanuel, Poncer Jean Christophe, Lévi Sabine

Abstract excerpt

The neuronal K/Cl transporter KCC2 exports chloride ions and thereby influences the efficacy and polarity of GABA signaling in the brain. KCC2 is also critical for dendritic spine morphogenesis and the maintenance of glutamatergic transmission in cortical neurons. Because KCC2 plays a pivotal role in the function of central synapses, it is of particular importance to understand the cellular and molecular...

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Identifiers

PMID: 24068817
DOI: 10.1523/JNEUROSCI.5889-12.2013
PMCID: PMC6618451

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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