Article
Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca2+/CaM Controls DCV Binding and Liprin-α/TANC2 Recruits DCVs to Postsynaptic Sites.
Cell reports - 17 Jul 2018
Stucchi Riccardo, Plucińska Gabriela, Hummel Jessica J A, Zahavi Eitan E, Guerra San Juan Irune, Klykov Oleg, Scheltema Richard A, Altelaar A F Maarten, Hoogenraad Casper C
Abstract excerpt
Tight regulation of neuronal transport allows for cargo binding and release at specific cellular locations. The mechanisms by which motor proteins are loaded on vesicles and how cargoes are captured at appropriate sites remain unclear. To better understand how KIF1A-driven dense core vesicle (DCV) transport is regulated, we identified the KIF1A interactome and focused on three binding partners, the calcium...
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