Article
ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 14 Mar 2012
Xiong Yulan, Yuan Changqing, Chen Rong, Dawson Ted M, Dawson Valina L
Abstract excerpt
Both sporadic and autosomal dominant forms of Parkinson's disease (PD) have been causally linked to mutations in leucine-rich repeat kinase 2 (LRRK2), a large protein with multiple domains. The kinase domain plays an important role in LRRK2-mediated toxicity. Although a number of investigations have focused on LRRK2 kinase activity, less is known about the GTPase function of LRRK2. The activity of GTPases is...
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