Article
Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily.
Human molecular genetics - 15 Apr 2014
Stafa Klodjan, Tsika Elpida, Moser Roger, Musso Alessandra, Glauser Liliane, Jones Amy, Biskup Saskia, Xiong Yulan, Bandopadhyay Rina, Dawson Valina L, Dawson Ted M, Moore Darren J
Abstract excerpt
Mutations in LRRK2 cause autosomal dominant Parkinson's disease (PD). LRRK2 encodes a multi-domain protein containing GTPase and kinase domains, and putative protein-protein interaction domains. Familial PD mutations alter the GTPase and kinase activity of LRRK2 in vitro. LRRK2 is suggested to regulate a number of cellular pathways although the underlying mechanisms are poorly understood. To explore such...
Topics
- Animals
- Blotting, Western
- Case-Control Studies
- Cells, Cultured
- Dynamin I
- Dynamin II
- Dynamin III
- Endocytosis
- Female
- GTP Phosphohydrolases