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Article

GTPase activity plays a key role in the pathobiology of LRRK2.

PLoS genetics - 8 Apr 2010

Xiong Yulan, Coombes Candice E, Kilaru Austin, Li Xiaojie, Gitler Aaron D, Bowers William J, Dawson Valina L, Dawson Ted M, Moore Darren J

Abstract excerpt

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with late-onset, autosomal-dominant, familial Parkinson's disease (PD) and also contribute to sporadic disease. The LRRK2 gene encodes a large protein with multiple domains, including functional Roc GTPase and protein kinas...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20386743
DOI: 10.1371/journal.pgen.1000902
PMCID: PMC2851569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20386743-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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